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Doña Isabel Moctezuma (born Tecuichpoch Ichcaxochitzin; 1509/1510 – 1550/1551) was a daughter of the Aztec ruler Moctezuma II. She was the consort of Atlixcatzin, a tlacateccatl, and of the Aztec emperors Cuitlahuac, and Cuauhtemoc and as such the last Aztec empress. After the Spanish conquest, Doña Isabel was recognized as Moctezuma's legitimate heir, and became one of the indigenous Mexicans granted an encomienda. Among the others were her half-sister Marina (or Leonor) Moctezuma, and Juan Sánchez, an Indian governor in Oaxaca.

Isabel was married to one tlacateccatl, two Aztec emperors and three Spaniards, and widowed five times. She had a daughter out of wedlock whom she refused to recognize, Leonor Cortés Moctezuma, with conquistador Hernán Cortés. Her sons founded a line of Spanish nobility. The title of Duke of Moctezuma de Tultengo descends from her brother, and still exists.